G*****s

Member of the Silvio O. Conti Center for the Neuroscience of Mental Disorders in the laboratory of the late Patricia Goldman-Rakic. Pioneered advanced techniques in studying receptor function in the working brain. Published breakthrough articles on the role of dopamine, serotonin, and GABA in the regulation of prefrontal function in relation to local microcircuitry. Supervised Ph.D. and MDPhD. graduate students as well as research assistants and postdoctoral research associates. Successfully applied for a N.A.R.S.A.D. Young Investigator Award. 2000 Principal Investigator on pilot project for NIAAA grant to the Center for the Translational Neuroscience of Alcoholism

Reorganization and supervision of leading imaging technologies and research. Development of PET imaging protocols, advanced analytical techniques and presentations to leading scientists and venture capitalists in the pharmaceutical industry. Joint organization with Dr. Stacy Castner of the Cognitive Neurosciences Program. Joint supervision of a graduate student, research assistant and research associate. Leading participation in strategic planning meetings. At the same time: Adjunct Associate Professor, Department of Biopharmaceutical Sciences, College of Pharmacy, Adjunct Assistant Professor, Department of Psychiatry, College of Medicine, University of Illinois at Chicago. I undertook this position to learn all the ins and outs of functional PET imaging, to develop my professional and managerial skills, and to further establish my relations with industry. Consultant, 1R43 MH069005-01 “Identification of Peptides Specific for D5 Receptor." Awarded Phase 1 SBIR 5R43MH070244-02.

Focused research on the potential of novel putative cognitive enhancers for the treatment of cognitive deficits and behavioral dysfunction in Schizophrenia. Investigations of the cellular mechanism involved. Mentor and supervisor to 2 postdoctoral research assistants and 2 graduate students. Laboratory manager with 7 technicians on multiple research projects. Consultant, collaborator and advisor to many internationally renowned colleagues in academia and industry. I was awarded an R01 grant from NIMH (PI: MH65552-01). Coinvestigator, 1R43 MH70244-01, PI and Co-PI on Yale/Pfizer Bioimaging Alliance. PI and Co-PI on Research awards funded by Big Pharma, including Pfizer, AstraZeneca, Eli Lilly, GSK and Fisher Laboratories. Continuation of the research with an increased focus on behavior and imaging and an expansion of scope to include studies of age-related cognitive decline and the mitigation of cognitive deficits in Alzheimer’s disease. PI on Pfizer funding for FDG-PET imaging. Awarded funding from the Huntington's Disease Foundation, as PI. Dedication to the study of putative cognitive enhancers for their potential benefit in age-related cognitive decline and early Alzheimer’s disease. Focus on geronic proteins and hormones, including the anti-aging protein Klotho. Co-Investigator of Project Grant from NIA on Geronic Proteins. PI on Investigator Award from the American Diabetes Association: “Breaking the Cycle of Hippocampal Damage and Hyperphagia.

Private enterprise designed to use flexible components and resources to generate the infrastructure for the best age-related research, including continued investigations of the klotho protein. Finding the best institutes and organizations with access to excellent staff, resources, equipment and scientific collaborators to get the best outcome for innovators in the field. Complete design of the experimental protocol, choosing the optimal tasks and adapting their design to best fit the needs of the study. Extensive monitoring and oversight of projects, data compilation, analysis, presentation and publication of the results. Designed and implemented study at the Department of Psychology, University of Wisconsin.

Investigation of the effects of serotonin and noradrenaline released by iontophoretic ejection or electrical stimulation on neuronal activity in the rat brainstem, spinal cord and hippocampus. Combined recording of unit activity and monoamine levels using Fast Cyclic Voltammetry. Development of recording, stimulation and voltammetric techniques. Funded by the UK Medical Research Council. Concurrent recording of neuronal activity and stimulated dopamine release in the neostriatum. Examination of concentration-dependent actions and comparison with effects of iontophoretic application of dopamine. Study of the heterogeneity of basal and stimulated dopamine release. Studies on changes in levels of endogenous ascorbate and pO2 correlated with unit activity in striatum and spinal cord. Development and assessment of Fast Differential Ramp Voltammetry in various forms. Funded by the Parkinson's Disease Society of the UK. Organization, teaching and assessment of post-graduate students in psychology at the School of Occupational Therapy while remaining research fellow in Physiology. Examined relationship of O2 utilization with ascorbate release in striatum and spinal cord; effects of D1 and D2 antagonists on correlations between stimulated dopamine release and neuronal activity; and stimulated dopamine-induced facilitation and GABAA -mediated inhibition of corticostriatal transmission using paired-pulse stimulation.